Win32 Write RAW Physical Disk Python 3.3.2 topic

Hello,
I am trying to write to the raw physical disk on Windows 8.1 but I
get an error:
PermissionError: [Errno 13] Permission denied: '\\.\PHYSICALDRIVE2\\'

OS: Windows 8.1
Python: 3.3.2
Drive is a USB drive
Running as administrator

Code Snippet:

with open(r"\.\PHYSICALDRIVE2\", "rb+") as f: #Writing Binary!
f.seek(unallocatedoffset + 0)
f.write(t1)


or

with open('\\.\PHYSICALDRIVE2\', "rb+") as f: #Writing Binary!
f.seek(unallocatedoffset + 0)
f.write(t1)

or

f = os.fdopen(os.open('\\.\PHYSICALDRIVE2\' os.O_CREAT |
os.O_WRONLY | os.O_APPEND | os.O_EXCL))


Any suggestions? Is it possible?